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24.2and pages 902-903, the section on the development of theeye). Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP (1996)Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivationdomain

Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP (1996)Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivationdomain. They found that studies of adultswere successful compared to studies with children.

Efficiency of recov-ery must be determined for these techniques to yield quantifiable data. Mitotic catastrophe is defined as the failure toarrest the cell cycle before or at mitosis, resulting in aberrantchromosome segregation

Mitotic catastrophe is defined as the failure toarrest the cell cycle before or at mitosis, resulting in aberrantchromosome segregation. Advanced computationalanatomy, hippocampal shape, and deformation tech-niques allow us to study the subregional hippocampalchanges (Csernansky et al., 2000; Thompson et al., 2004).For example, the hippocampal radial distance mappingapproach (which models the hippocampal structure in 3D)computes hippocampal thickness at each surface point.Using the radial distance or other conceptually relatedapproaches, researchers have now mapped the progressionof AD pathology through the hippocampal structure invivo (Csernansky et al., 2000, 2005; Apostolova et al., 2006a,2006b, 2010c) and documented the spread of hippocam-pal atrophy from the subiculum and CA1 subfield to theCA2-3 region—a pattern that was previously capturedin only postmortem studies (Schonheit et al., 2004). Simply becausechange is associated with an intervention does not necessarily mean that the observedchange was caused by the intervention. Though acyclovir eye ointment actsslower than idoxuridine eye drops, blindness canbe prevented.

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