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Treatment with oral antibiotic is usually started with a large dose to quickly bring the population of the colonizing bacteria down. A pregnant woman who has a high risk of IE does NOT usually need antibiotic prophylaxis before a normal vaginal delivery or cesarean section. An endogenous gene can be operatively linked to a tet operator sequence(s) by homologous recombination between a recombination vector comprising a TRE and sequences of the endogeneous gene. This is because the FDA regulates the testing and approval of drugs, meclizine dramamine but not how doctors use drugs to treat their patients.

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